Caenorhabditis elegans

PMK-1

CELE_B0218.3, B0218.3
pmk-1 encodes a mitogen-activated protein kinase (MAPK), orthologous to human p38 MAPK (OMIM:600289); PMK-1 is an essential component of the MAPK pathway that regulates the innate immune response; PMK-1 is required, upstream of CED-9, for eliciting gonadal programmed cell death in response to Salmonella enterica infection; PMK-1 physically interacts with the ATF-7 transcription factor to regulate the transcriptional innate immune response and phosphorylation of ATF-7 is dependent upon PMK-1 and SEK-1.

External Database Linkouts

WormBase | Entrez Gene | RefSeq | UniprotKB
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  • Interactors (22)
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