The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance.
Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence point in a signaling pathway engaged by multiple R genes. Here, we show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. Silencing the ... barley gene Sgt1 reveals its role in R gene-triggered, Rar1-dependent disease resistance. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination.
Mesh Terms:
Amino Acid Motifs, Amino Acid Sequence, Arabidopsis, Arabidopsis Proteins, Carrier Proteins, Cell Cycle Proteins, Gene Silencing, Genes, Fungal, Genes, Plant, Hordeum, Immunity, Innate, Molecular Sequence Data, Multiprotein Complexes, Peptide Hydrolases, Peptide Synthases, Plant Diseases, Plant Proteins, Protein Structure, Tertiary, Proteins, Recombinant Fusion Proteins, SKP Cullin F-Box Protein Ligases, Saccharomyces cerevisiae Proteins, Sequence Alignment, Signal Transduction, Two-Hybrid System Techniques, Ubiquitin
Amino Acid Motifs, Amino Acid Sequence, Arabidopsis, Arabidopsis Proteins, Carrier Proteins, Cell Cycle Proteins, Gene Silencing, Genes, Fungal, Genes, Plant, Hordeum, Immunity, Innate, Molecular Sequence Data, Multiprotein Complexes, Peptide Hydrolases, Peptide Synthases, Plant Diseases, Plant Proteins, Protein Structure, Tertiary, Proteins, Recombinant Fusion Proteins, SKP Cullin F-Box Protein Ligases, Saccharomyces cerevisiae Proteins, Sequence Alignment, Signal Transduction, Two-Hybrid System Techniques, Ubiquitin
Science
Date: Mar. 15, 2002
PubMed ID: 11847307
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