CELE_Y105E8A.5, Y105E8A.5

bbs-1 encodes the C. elegans ortholog of human BBS1, a protein containing a predicted beta-propeller domain; bbs-1 is a component of and is required for proper intraflagellar transport (IFT); bbs-1 acts in ciliated neurons in a pathway along with kat-1/3-ketoacyl-coA thiolase, tub-1/tubby and other genes involved in ciliary structure and function to regulate fat storage, as such, bbs-1 affects body size, feeding and chemosensation; bbs-1 is also required for the proper regulation of insulin secretion; bbs-1, bbs-5, bbs-8 and bbs-9 mutants along with ciliary phenotypes show an increased secretion of insulin, biogenic amines and neuropeptides which requires the Rab27/AEX-6 dense-core vesicle exocytosis machinery; BBS-1::GFP reporter fusion is expressed exclusively in ciliated neurons, where it localizes to the transition zones and along the ciliary axonemes; the bbs-1 5' untranslated region contains an X box, a regulatory element found in many genes expressed in ciliated neurons, that functions as a binding site for the DAF-19 transcription factor.

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