CELE_R119.4, prp-1, R119.4

pqn-59 encodes a protein containing a glutamine/asparagine (Q/N)-rich domain and similarity to the vertebrate ubiquitin-associated proteins UBAP2 and UBAP2L; microarray experiments indicate that pqn-59 is expressed maternally and embryonically and in situ hybridization studies show that pqn-59 mRNA exhibits strong germline expression; loss of pqn-59 activity via RNAi in a wild-type background results in eggs that are smaller than normal, embryonic and larval lethality, and animals that are sick with smaller than normal brood sizes; pqn-59(RNAi) in an rrf-3 background additionally results in uncoordinated locomotion, consistent with the presence of pqn-59 transcripts in motor neurons.

57308

6239