Caenorhabditis elegans
SMO-1
CELE_K12C11.2, SMT3, K12C11.2
smo-1 encodes the C. elegans ortholog of SUMO, a small ubiquitin-like moiety that, when attached to protein substrates, regulates their subcellular localization and activity; smo-1 is an essential gene: loss of its activity results in embryonic and larval lethality; in addition, smo-1 mutants have defects in synaptonemal complex disassembly and bivalent formation, enhance meiotic defects of zhp-3::gfp mutants and show mislocalization of ZHP-3 in late pachytene; smo-1 is also required for reproductive system development, where its target may be the LIN-11 LIM homeodomain protein.
GO Process (12)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
- body morphogenesis [IMP]
- collagen and cuticulin-based cuticle development [IMP]
- embryo development [IMP]
- embryo development ending in birth or egg hatching [IMP]
- hermaphrodite genitalia development [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of vulval development [IMP]
- nematode larval development [IMP]
- protein localization to chromosome [IMP]
- reproduction [IMP]
- synaptonemal complex disassembly [IGI, IMP]
- vulval development [IMP]
Gene Ontology Molecular Function
Download Curated Data for this Protein
57309
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- Interactors 74
- Interactions 99
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