CELE_Y71F9AL.18, Y71F9AL.18

pme-1 encodes a poly(ADP-ribose) polymerase (PARP) orthologous to human PARP1 (OMIM:173870); PME-1 has two N-terminal zinc fingers that probably bind DNA, and a C-terminal catalytic domain; PME-1 has PARP activity in vitro, which is blocked by mammalian PARP inhibitors; since these inhibitors also cause embryonic lethality in worms exposed to ionizing radiation, PME-1 is likely to be required in vivo for repairing broken DNA.

57311

6239