Caenorhabditis elegans
PME-1
CELE_Y71F9AL.18, Y71F9AL.18
pme-1 encodes a poly(ADP-ribose) polymerase (PARP) orthologous to human PARP1 (OMIM:173870); PME-1 has two N-terminal zinc fingers that probably bind DNA, and a C-terminal catalytic domain; PME-1 has PARP activity in vitro, which is blocked by mammalian PARP inhibitors; since these inhibitors also cause embryonic lethality in worms exposed to ionizing radiation, PME-1 is likely to be required in vivo for repairing broken DNA.
GO Process (0)
GO Function (0)
GO Component (0)
Download Curated Data for this Protein
57311
6239
Switch View:
- Interactors 8
- Interactions 8
- Network