Caenorhabditis elegans
DSH-2
CELE_C27A2.6, C27A2.6
dsh-2 encodes one of three C. elegans Dishevelled (Dsh) homologs; during embryonic development, dsh-2 functions in the Wnt signaling pathway that specifies endoderm and orients the division axis of the EMS blastomere; dsh-2 is also required for many neuronal cell fate specifications and for asymmetric cell division in the early somatic gonad; dsh-2 is additionally required for proper hypodermal morphogenesis during embryonic elongation; DSH-2 is expressed in the embryo from the early stages of embryogenesis through the ~1.5-fold stage; DSH-2 is also expressed in the somatic gonad precursors Z1 and Z4; DSH-2 localizes to the cell cortex.
GO Process (19)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- Wnt signaling pathway [IGI]
- Wnt signaling pathway, planar cell polarity pathway [IBA]
- Wnt signaling pathway, regulating spindle positioning [IGI, IMP]
- asymmetric cell division [IMP]
- asymmetric protein localization [IMP]
- body morphogenesis [IMP]
- canonical Wnt signaling pathway [IBA]
- cell fate specification [IGI, IMP]
- digestive tract morphogenesis [IMP]
- embryo development ending in birth or egg hatching [IMP]
- embryonic morphogenesis [IMP]
- endodermal cell fate specification [IGI]
- establishment of mitotic spindle orientation [IGI]
- gonad morphogenesis [IMP]
- hermaphrodite genitalia development [IMP]
- locomotion [IMP]
- nematode larval development [IMP]
- regulation of signaling [IBA]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
57341
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- Interactors 52
- Interactions 66
- Network