Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1.
Hgs/Hrs is a tyrosine-phosphorylated FYVE finger protein that is induced by stimulation with various cytokines and growth factors. Here we show that Hgs plays critical roles in the signaling pathway for the interleukin-2-induced activation of the serum-response element and cyclic AMP-response element of the c-fos promoter. We found that Hgs ... associated physically with transforming growth factor-beta-activated kinase 1 (TAK1) and p21-activated kinase 1 (Pak1), which mediate the activation of c-Jun N-terminal kinase and serum response factor, respectively, leading to transactivation via the serum-response element and cyclic AMP-response element. These results suggest that Hgs is involved in the TAK1-JNK and Pak1-serum response factor pathways for the c-fos induction that is initiated by cytokines.
Mesh Terms:
Animals, Base Sequence, Cell Line, Cytokines, DNA-Binding Proteins, Enzyme Activation, Genes, Dominant, Genes, Reporter, Granulocyte-Macrophage Colony-Stimulating Factor, Humans, Immunoblotting, Interleukin-2, JNK Mitogen-Activated Protein Kinases, Luciferases, MAP Kinase Kinase Kinases, Mice, Mitogen-Activated Protein Kinases, Molecular Sequence Data, Nuclear Proteins, Phosphorylation, Plasmids, Precipitin Tests, Promoter Regions, Genetic, Protein Binding, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins c-fos, Serum Response Factor, Signal Transduction, Time Factors, Transcriptional Activation, Tyrosine, p21-Activated Kinases
Animals, Base Sequence, Cell Line, Cytokines, DNA-Binding Proteins, Enzyme Activation, Genes, Dominant, Genes, Reporter, Granulocyte-Macrophage Colony-Stimulating Factor, Humans, Immunoblotting, Interleukin-2, JNK Mitogen-Activated Protein Kinases, Luciferases, MAP Kinase Kinase Kinases, Mice, Mitogen-Activated Protein Kinases, Molecular Sequence Data, Nuclear Proteins, Phosphorylation, Plasmids, Precipitin Tests, Promoter Regions, Genetic, Protein Binding, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins c-fos, Serum Response Factor, Signal Transduction, Time Factors, Transcriptional Activation, Tyrosine, p21-Activated Kinases
J. Biol. Chem.
Date: Aug. 10, 2001
PubMed ID: 11397816
View in: Pubmed Google Scholar
Download Curated Data For This Publication
5813
Switch View:
- Interactions 2