Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression.
The proto-oncogene product Vav plays a critical role in hematopoietic signal transduction. By using the yeast two-hybrid system, we identified a novel human protein, ENX-1, which interacts specifically with Vav both in vitro and in vivo. ENX-1 represents the human homolog of the Drosophila Enhancer of zeste gene, a member ... of the Polycomb group of genes, which are transcriptional regulators of homeobox gene expression. Interaction with ENX-1 suggests that Vav functions as an upstream element in the transcriptional regulation of homeobox genes, known to be important effectors in the hematopoietic system.
Mesh Terms:
Amino Acid Sequence, Animals, Binding Sites, Cell Cycle Proteins, Cloning, Molecular, DNA, Complementary, Drosophila, Drosophila Proteins, Gene Expression Regulation, Genes, Homeobox, Genes, Insect, Hematopoiesis, Humans, Molecular Sequence Data, Nuclear Proteins, Protein Binding, Proteins, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-vav, Repressor Proteins, Saccharomyces cerevisiae, Sequence Homology, Amino Acid, Signal Transduction
Amino Acid Sequence, Animals, Binding Sites, Cell Cycle Proteins, Cloning, Molecular, DNA, Complementary, Drosophila, Drosophila Proteins, Gene Expression Regulation, Genes, Homeobox, Genes, Insect, Hematopoiesis, Humans, Molecular Sequence Data, Nuclear Proteins, Protein Binding, Proteins, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-vav, Repressor Proteins, Saccharomyces cerevisiae, Sequence Homology, Amino Acid, Signal Transduction
Mol. Cell. Biol.
Date: Jun. 01, 1996
PubMed ID: 8649418
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