Novel signaling pathway suggested by SH3 domain-mediated p95vav/heterogeneous ribonucleoprotein K interaction.

The role of the protooncogene product p95vav in signal transduction was investigated by characterizing its interactions with proteins that may represent components of a novel signaling pathway. We demonstrate here stable association of p95vav with the heterogeneous ribonucleoprotein K (hnRNP-K), a protein that not only was found to be part ...
of hnRNP particles but has also been implicated in transcriptional regulation of the c-myc gene. Through the PLPPPPPPRG sequence, hnRNP-K specifically interacts with the SH3 domain of p95vav and thus represents a novel SH3 binding protein that may be capable of translating cell surface receptor signals through p95vav activation into regulatory events on the level of gene expression.
Mesh Terms:
Amino Acid Sequence, Base Sequence, Cell Cycle Proteins, Cell Line, Humans, Molecular Sequence Data, Oligodeoxyribonucleotides, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-vav, Ribonucleoproteins, Signal Transduction
J. Biol. Chem.
Date: Aug. 12, 1994
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