Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.
The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted in the stabilization of their interactions, thus facilitating Cbl-induced ubiquitination ... and subsequent degradation of c-Abl and ArgBP2.
Mesh Terms:
Animals, CHO Cells, Cricetinae, Homeodomain Proteins, Humans, Hydrolysis, Oncogene Protein v-cbl, Phosphorylation, Protein Binding, Proto-Oncogene Proteins c-abl, Retroviridae Proteins, Oncogenic, Two-Hybrid System Techniques, Ubiquitin
Animals, CHO Cells, Cricetinae, Homeodomain Proteins, Humans, Hydrolysis, Oncogene Protein v-cbl, Phosphorylation, Protein Binding, Proto-Oncogene Proteins c-abl, Retroviridae Proteins, Oncogenic, Two-Hybrid System Techniques, Ubiquitin
Biochem. J.
Date: Feb. 15, 2003
PubMed ID: 12475393
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