Caenorhabditis elegans

SAP-49

CELE_C08B11.5, C08B11.5
sap-49 encodes the C. elegans ortholog of mammalian SAP49, a component of the SF3b splicing factor, a U2 snRNP-associated protein complex; loss of sap-49 activity via RNAi results in embryonic lethality, a protruding vulva, reduced levels of gene expression (as assessed by a gfp reporter), and early onset of foci formation in strains expressing polyglutamine-YFP; SAP-49 exhibits sequence-specific RNA binding in vitro; sap-49 mRNA is expressed at all developmental stages, while a SAP-49::lacZ translational fusion protein is reportedly expressed in specific cells, including pharyngeal muscles, in larvae and adults.

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WormBase | Entrez Gene | RefSeq | UniprotKB
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