Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors.
A protein named nuclear receptor binding factor-2 (NRBF-2) was identified by yeast two-hybrid screening, as an interaction partner of peroxisome proliferator-activated receptor alpha as well as several other nuclear receptors. NRBF-2 exhibited a gene activation function, when tethered to a heterologous DNA binding domain, in both mammalian cells and yeast.
Mesh Terms:
Amino Acid Sequence, Animals, Base Sequence, Gene Expression Regulation, Liver, Molecular Sequence Data, Plasmids, Rats, Receptors, Cell Surface, Receptors, Cytoplasmic and Nuclear, Sequence Alignment, Trans-Activators, Transcription Factors, Transcriptional Activation, Tumor Cells, Cultured
Amino Acid Sequence, Animals, Base Sequence, Gene Expression Regulation, Liver, Molecular Sequence Data, Plasmids, Rats, Receptors, Cell Surface, Receptors, Cytoplasmic and Nuclear, Sequence Alignment, Trans-Activators, Transcription Factors, Transcriptional Activation, Tumor Cells, Cultured
Biochim. Biophys. Acta
Date: Jan. 31, 2000
PubMed ID: 10786636
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