Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors.

A protein named nuclear receptor binding factor-2 (NRBF-2) was identified by yeast two-hybrid screening, as an interaction partner of peroxisome proliferator-activated receptor alpha as well as several other nuclear receptors. NRBF-2 exhibited a gene activation function, when tethered to a heterologous DNA binding domain, in both mammalian cells and yeast.
Mesh Terms:
Amino Acid Sequence, Animals, Base Sequence, Gene Expression Regulation, Liver, Molecular Sequence Data, Plasmids, Rats, Receptors, Cell Surface, Receptors, Cytoplasmic and Nuclear, Sequence Alignment, Trans-Activators, Transcription Factors, Transcriptional Activation, Tumor Cells, Cultured
Biochim. Biophys. Acta
Date: Jan. 31, 2000
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