Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways.
Wiskott-Aldrich syndrome is an X-linked combined immunodeficiency affecting cells of several different hemopoietic lineages. The Wiskott-Aldrich syndrome protein (WASP), which has no homology with any other known protein families, is rich in proline motifs known to contribute to Src homology 3 binding sites. However, its function has not been determined. ... The Tec family of cytoplasmic tyrosine kinases, which include Btk (the X-linked agammaglobulinemia gene), Itk, and Tec, is thought to be involved in lymphoid cell signaling pathways. In this work, we show binding of WASP to the Src homology 3 domains of Btk, Itk, Tec, Grb2, and phospholipase C-gamma, which suggests a function for WASP in lymphoid cell signaling.
Mesh Terms:
Amino Acid Sequence, B-Lymphocytes, Binding Sites, Burkitt Lymphoma, Cell Differentiation, Cell Line, Transformed, Gene Expression, Humans, Molecular Sequence Data, Peptide Fragments, Proline, Protein Binding, Proteins, Recombinant Fusion Proteins, Signal Transduction, Tumor Cells, Cultured, Wiskott-Aldrich Syndrome, Wiskott-Aldrich Syndrome Protein, src Homology Domains, src-Family Kinases
Amino Acid Sequence, B-Lymphocytes, Binding Sites, Burkitt Lymphoma, Cell Differentiation, Cell Line, Transformed, Gene Expression, Humans, Molecular Sequence Data, Peptide Fragments, Proline, Protein Binding, Proteins, Recombinant Fusion Proteins, Signal Transduction, Tumor Cells, Cultured, Wiskott-Aldrich Syndrome, Wiskott-Aldrich Syndrome Protein, src Homology Domains, src-Family Kinases
J. Immunol.
Date: Nov. 01, 1996
PubMed ID: 8892607
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