LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes.
In the present study, we describe a novel inhibitory receptor, leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), that is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 is a 32 kDa transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. ... LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell-mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize human leukocyte antigen (HLA) class I molecules and thus represents a novel HLA class I-independent mechanism of NK cell regulation.
Mesh Terms:
Amino Acid Sequence, Base Sequence, Cloning, Molecular, DNA, Complementary, HL-60 Cells, Humans, Intracellular Signaling Peptides and Proteins, Jurkat Cells, Killer Cells, Natural, Leukocytes, Mononuclear, Molecular Sequence Data, Protein Binding, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Protein Tyrosine Phosphatases, RNA, Messenger, Receptors, Immunologic, Tumor Cells, Cultured
Amino Acid Sequence, Base Sequence, Cloning, Molecular, DNA, Complementary, HL-60 Cells, Humans, Intracellular Signaling Peptides and Proteins, Jurkat Cells, Killer Cells, Natural, Leukocytes, Mononuclear, Molecular Sequence Data, Protein Binding, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Protein Tyrosine Phosphatases, RNA, Messenger, Receptors, Immunologic, Tumor Cells, Cultured
Immunity
Date: Aug. 01, 1997
PubMed ID: 9285412
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