BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.

During activation, T cells express receptors for receiving positive and negative costimulatory signals. Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed ...
on T helper type 1 (T(H)1) but not T(H)2 cells. Crosslinking BTLA with antigen receptors induces its tyrosine phosphorylation and association with the Src homology domain 2 (SH2)-containing protein tyrosine phosphatases SHP-1 and SHP-2, and attenuates production of interleukin 2 (IL-2). BTLA-deficient T cells show increased proliferation, and BTLA-deficient mice have increased specific antibody responses and enhanced sensitivity to experimental autoimmune encephalomyelitis. B7x, a peripheral homolog of B7, is a ligand of BTLA. Thus, BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).
Mesh Terms:
Amino Acid Sequence, Animals, Antigens, CD, Antigens, CD80, Antigens, Differentiation, Antigens, Surface, Apoptosis Regulatory Proteins, Encephalomyelitis, Autoimmune, Experimental, Immunoconjugates, Interleukin-2, Intracellular Signaling Peptides and Proteins, Lymphocyte Activation, Mice, Molecular Sequence Data, Phosphorylation, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Protein Tyrosine Phosphatases, Proteins, RNA, Messenger, Receptors, Immunologic, T-Lymphocytes
Nat. Immunol.
Date: Jul. 01, 2003
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