A distinct type of cyclin D, CYCD4;2, involved in the activation of cell division in Arabidopsis.

The Arabidopsis genome encodes 10 D-type cyclins (CYCD); however, their differential role in cell cycle control is not well known. Among them, CYCD4;2 is unique in the amino acid sequence; namely, it lacks the Rb-binding motif and the PEST sequence that are conserved in CYCDs. Here, we have shown that ...
CYCD4;2 suppressed G1 cyclin mutations in yeast and formed a kinase complex with CDKA;1, an ortholog of yeast Cdc28, in insect cells. Hypocotyl explants of CYCD4;2 over-expressing plants showed faster induction of calli than wild-type explants on a medium containing lower concentration of auxin. These results suggest that CYCD4;2 has a promotive function in cell division by interacting with CDKA;1 regardless of the unusual primary sequence.
Mesh Terms:
Animals, Arabidopsis, Arabidopsis Proteins, CDC28 Protein Kinase, S cerevisiae, Cell Division, Cell Line, Cyclin D, Cyclin-Dependent Kinases, Cyclins, Hypocotyl, Insects, Protein Binding, Yeasts
Plant Cell Rep.
Date: Jun. 01, 2006
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