Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the Jak/STAT signal transduction pathway in Drosophila.
The JAK/STAT signal transduction pathway regulates many developmental processes in Drosophila. However, the functional mechanism of this pathway is poorly understood. In this report, we identify the Drosophila cyclin-dependent kinase 4 (Cdk4), which exhibits embryonic mutant phenotypes identical to those in the Hopscotch/JAK kinase and stat92E/STAT mutations. Specific genetic interactions ... between Cdk4 and hop mutations suggest that Cdk4 functions downstream of the HOP tyrosine kinase. We further show that Cyclin D-Cdk4 (as well as Cyclin E-Cdk2) binds and regulates STAT92E protein stability. STAT92E regulates gene expression for various biological processes, including the endocycle S phase. These data suggest that Cyclin D-Cdk4 and Cyclin E-Cdk2 play more versatile roles in Drosophila development.
Mesh Terms:
Animals, Animals, Genetically Modified, Body Patterning, CDC2-CDC28 Kinases, Cell Differentiation, Cell Polarity, Crosses, Genetic, Cyclin D, Cyclin E, Cyclin-Dependent Kinase 2, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinases, Cyclins, DNA-Binding Proteins, Drosophila Proteins, Drosophila melanogaster, Embryo, Nonmammalian, Enzyme Activation, Eye, Female, Gene Expression Regulation, Developmental, Glycoproteins, In Situ Hybridization, Insect Proteins, Janus Kinase 1, Janus Kinases, Mutation, Oogenesis, Ovarian Follicle, Phenotype, Protein-Serine-Threonine Kinases, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, STAT Transcription Factors, Signal Transduction, Trans-Activators, Transcription Factors
Animals, Animals, Genetically Modified, Body Patterning, CDC2-CDC28 Kinases, Cell Differentiation, Cell Polarity, Crosses, Genetic, Cyclin D, Cyclin E, Cyclin-Dependent Kinase 2, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinases, Cyclins, DNA-Binding Proteins, Drosophila Proteins, Drosophila melanogaster, Embryo, Nonmammalian, Enzyme Activation, Eye, Female, Gene Expression Regulation, Developmental, Glycoproteins, In Situ Hybridization, Insect Proteins, Janus Kinase 1, Janus Kinases, Mutation, Oogenesis, Ovarian Follicle, Phenotype, Protein-Serine-Threonine Kinases, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, STAT Transcription Factors, Signal Transduction, Trans-Activators, Transcription Factors
Dev. Cell
Date: Feb. 01, 2003
PubMed ID: 12586062
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