Mitogen-activated protein kinase Hog1 is essential for the response to arsenite in Saccharomyces cerevisiae.
Here we describe, for the first time, that budding yeast mitogen-activated protein kinase Hog1 and its upstream activators Pbs2 and Ssk1 are essential for the response to arsenite. Hog1 is rapidly phosphorylated in response to arsenite and triggers a transcriptional response that involves the upregulation of genes essential for arsenite ... detoxification.
Mesh Terms:
Arsenites, Gene Expression Regulation, Fungal, Mitogen-Activated Protein Kinases, Mutation, Phosphorylation, Protein Transport, RNA, Messenger, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Arsenites, Gene Expression Regulation, Fungal, Mitogen-Activated Protein Kinases, Mutation, Phosphorylation, Protein Transport, RNA, Messenger, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Eukaryotic Cell
Date: Oct. 01, 2006
PubMed ID: 16920868
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