The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction.

Cellular systems allow transition-metal ions to reach or leave the cell or intracellular locations through metal transfer between proteins. By coupling mutagenesis and advanced NMR experiments, we structurally characterized the adduct between the copper chaperone Atx1 and the first copper(I)-binding domain of the Ccc2 ATPase. Copper was required for the ...
interaction. This study provides an understanding of metal-mediated protein-protein interactions in which the metal ion is essential for the weak, reversible interaction between the partners.
Mesh Terms:
Carrier Proteins, Cation Transport Proteins, Copper, Ligands, Models, Molecular, Nuclear Magnetic Resonance, Biomolecular, Protein Binding, Protein Structure, Quaternary, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Nat. Chem. Biol.
Date: Jul. 01, 2006
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