Interaction of a Golgi-associated kinesin-like protein with Rab6.
Rab guanosine triphosphatases regulate vesicular transport and membrane traffic within eukaryotic cells. Here, a kinesin-like protein that interacts with guanosine triphosphate (GTP)-bound forms of Rab6 was identified. This protein, termed Rabkinesin-6, was localized to the Golgi apparatus and shown to play a role in the dynamics of this organelle. The ... carboxyl-terminal domain of Rabkinesin-6, which contains the Rab6-interacting domain, inhibited the effects of Rab6-GTP on intracellular transport. Thus, a molecular motor is a potential effector of a Rab protein, and coordinated action between members of these two families of proteins could control membrane dynamics and directional vesicular traffic.
Mesh Terms:
Adenosine Triphosphatases, Alkaline Phosphatase, Amino Acid Sequence, Biological Transport, Carrier Proteins, Endoplasmic Reticulum, Golgi Apparatus, Guanosine Triphosphate, Hela Cells, Humans, Kinesin, Microtubules, Molecular Sequence Data, Molecular Weight, rab GTP-Binding Proteins, ras Proteins
Adenosine Triphosphatases, Alkaline Phosphatase, Amino Acid Sequence, Biological Transport, Carrier Proteins, Endoplasmic Reticulum, Golgi Apparatus, Guanosine Triphosphate, Hela Cells, Humans, Kinesin, Microtubules, Molecular Sequence Data, Molecular Weight, rab GTP-Binding Proteins, ras Proteins
Science
Date: Jan. 23, 1998
PubMed ID: 9438855
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