Condensin is required for chromosome arm cohesion during mitosis.

We describe a novel requirement for the condensin complex in sister chromatid cohesion in Saccharomyces cerevisiae. Strikingly, condensin-dependent cohesion can be distinguished from cohesin-based pairing by a number of criteria. First, condensin is required to maintain cohesion at several chromosomal arm sites but, in contrast to cohesin, is not required ...
at either centromere or telomere-proximal loci. Second, condensin-dependent interlinks are established during mitosis independently of DNA replication and are reversible within a single cell cycle. Third, the loss of condensin-dependent linkages occurs without affecting cohesin levels at the separated URA3 locus. We propose that, during mitosis, robust sister chromatid cohesion along chromosome arms requires both condensinand cohesin-dependent mechanisms, which function independently of each other. We discuss the implications of our results for current models of sister chromatid cohesion.
Mesh Terms:
Adenosine Triphosphatases, Cell Cycle, Cell Cycle Proteins, Cell Division, Chromatids, Chromosomal Proteins, Non-Histone, Chromosome Pairing, Chromosomes, DNA-Binding Proteins, Mitosis, Multiprotein Complexes, Nuclear Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Genes Dev.
Date: Nov. 01, 2006
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