Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2.
Inherited mutations in the human BRCA2 gene cause about half of the cases of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair protein Rad51. Developmental arrest in Brca2-deficient embryos, their radiation sensitivity, ... and the association of Brca2 with Rad51 indicate that Brca2 may be an essential cofactor in the Rad51-dependent DNA repair of double-strand breaks, thereby explaining the tumour-suppressor function of Brca2.
Mesh Terms:
3T3 Cells, Animals, BRCA2 Protein, Blastocyst, Brain, Cell Division, Cell Survival, DNA-Binding Proteins, Embryo, Mammalian, Embryonic and Fetal Development, Female, Gamma Rays, Gene Expression, Gene Targeting, Genes, Tumor Suppressor, In Situ Hybridization, Male, Mice, Molecular Sequence Data, Mutagenesis, Neoplasm Proteins, Polymerase Chain Reaction, Protein Binding, Rad51 Recombinase, Radiation Tolerance, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Stem Cells, Transcription Factors
3T3 Cells, Animals, BRCA2 Protein, Blastocyst, Brain, Cell Division, Cell Survival, DNA-Binding Proteins, Embryo, Mammalian, Embryonic and Fetal Development, Female, Gamma Rays, Gene Expression, Gene Targeting, Genes, Tumor Suppressor, In Situ Hybridization, Male, Mice, Molecular Sequence Data, Mutagenesis, Neoplasm Proteins, Polymerase Chain Reaction, Protein Binding, Rad51 Recombinase, Radiation Tolerance, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Stem Cells, Transcription Factors
Nature
Date: Apr. 24, 1997
PubMed ID: 9126738
View in: Pubmed Google Scholar
Download Curated Data For This Publication
7051
Switch View:
- Interactions 3