Linking the Rb and polycomb pathways.
Polycomb group (PcG) proteins associate to form complexes that repress Hox genes, thereby imposing the patterning of Hox expression required for development. However, these proteins have a second Hox-independent role in regulating cell proliferation. Our results suggest that association between Rb and PcG proteins forms a repressor complex that blocks ... entry of cells into mitosis. Also, we provide evidence that Rb colocalizes with nuclear PcG complexes and is important for association of PcG complexes with nuclear targets. The Rb-PcG complex may provide a means to link cell cycle arrest to differentiation events leading to embryonic pattern formation.
Mesh Terms:
Alcohol Oxidoreductases, Animals, CDC2 Protein Kinase, Cell Cycle, Cell Cycle Proteins, Cell Nucleus, Cyclin A, Cyclin E, DNA-Binding Proteins, E2F Transcription Factors, Fungal Proteins, Genes, Reporter, Histone Deacetylase 1, Histone Deacetylases, Humans, Immunoblotting, Macromolecular Substances, Microscopy, Fluorescence, Phosphoproteins, Promoter Regions, Genetic, Recombinant Fusion Proteins, Repressor Proteins, Retinoblastoma Protein, Saccharomyces cerevisiae Proteins, Trans-Activators, Transcription Factors, Transcription, Genetic, Tumor Cells, Cultured
Alcohol Oxidoreductases, Animals, CDC2 Protein Kinase, Cell Cycle, Cell Cycle Proteins, Cell Nucleus, Cyclin A, Cyclin E, DNA-Binding Proteins, E2F Transcription Factors, Fungal Proteins, Genes, Reporter, Histone Deacetylase 1, Histone Deacetylases, Humans, Immunoblotting, Macromolecular Substances, Microscopy, Fluorescence, Phosphoproteins, Promoter Regions, Genetic, Recombinant Fusion Proteins, Repressor Proteins, Retinoblastoma Protein, Saccharomyces cerevisiae Proteins, Trans-Activators, Transcription Factors, Transcription, Genetic, Tumor Cells, Cultured
Mol. Cell
Date: Sep. 01, 2001
PubMed ID: 11583618
View in: Pubmed Google Scholar
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