Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product.

Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
We have cloned a gene, BDP, encoding a protein with homology to the retinoblastoma-binding proteins Rbp1 and Rbp2. It also has homology to DNA-binding proteins such as Bright, a B-cell-specific trans-activator, and the Drosophila melanogaster dead ringer gene product. Like MyoD, Bdp binds to the COOH-terminal region of pRb through its conserved region and to hypophosphorylated pRb. It also binds to the MAR of the immunoglobulin heavy-chain locus. Thus Bdp may contribute to the transcriptional regulation of genes involved in differentiation and tissue-specific expression.
Mesh Terms:
Amino Acid Sequence, Animals, Base Sequence, Binding Sites, Brain Neoplasms, Chromosome Mapping, Chromosomes, Human, Pair 15, DNA, Complementary, DNA-Binding Proteins, Drosophila Proteins, Drosophila melanogaster, Expressed Sequence Tags, Gene Library, Glioblastoma, Hela Cells, Homeodomain Proteins, Humans, Insect Proteins, Molecular Sequence Data, Molecular Weight, Multigene Family, Neoplasm Proteins, Nuclear Proteins, Oncogenes, Phosphorylation, Protein Binding, Protein Processing, Post-Translational, Recombinant Fusion Proteins, Retinoblastoma Protein, Sequence Alignment, Sequence Homology, Amino Acid, Trans-Activators, Transfection, Tumor Cells, Cultured
Cancer Res. Aug. 01, 1999; 59(15);3741-7 [PUBMED:10446990]
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