Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins.
Transcriptional coactivators SRC-1 and p300 specifically interact with liganded-nuclear receptors and also modulate other transcription factors, including serum response factor (SRF). Here, we report that retinoids repress transactivation by SRF and specific interactions exist between the DNA binding domains of SRF and retinoic acid and retinoid X receptors. We further ... demonstrate that the repression may involve retinoid-dependent competition for a limiting amount of SRC-1 and p300 between SRF and retinoid receptors. We propose that the well-defined anti-proliferative action of retinoids could, at least in part, result from this novel transrepressive action on the mitogenic transcription factor SRF.
Mesh Terms:
Animals, Cell Division, Cells, Cultured, DNA-Binding Proteins, E1A-Associated p300 Protein, Hela Cells, Histone Acetyltransferases, Humans, Models, Genetic, Nuclear Proteins, Nuclear Receptor Coactivator 1, Rats, Receptors, Retinoic Acid, Serum Response Factor, Trans-Activators, Transcription Factors, Transcriptional Activation, Tretinoin
Animals, Cell Division, Cells, Cultured, DNA-Binding Proteins, E1A-Associated p300 Protein, Hela Cells, Histone Acetyltransferases, Humans, Models, Genetic, Nuclear Proteins, Nuclear Receptor Coactivator 1, Rats, Receptors, Retinoic Acid, Serum Response Factor, Trans-Activators, Transcription Factors, Transcriptional Activation, Tretinoin
Oncogene
Date: Oct. 04, 2001
PubMed ID: 11641790
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