Interaction of BCR-ABL with the retinoblastoma protein in Philadelphia chromosome-positive cell lines.
The tyrosine kinase activity of BCR-ABL fusion proteins plays an important role in the pathogenesis of leukemia that is for the Philadelphia chromosome (Ph1). Because nuclear c-ABL is regulated during the cell cycle through a specific interaction with the retinoblastoma protein (pRB), the possible interaction of BCR-ABL with pRB in ... Ph1-positive cell lines was investigated. P145 c-ABL as well as P190 and P210 BCR-ABL proteins interacted with pRB. Furthermore, c-ABL and BCR-ABL associated with both phosphorylated and nonphosphorylated forms of pRB. These findings suggest that BCR-ABL interferes with pRB function and thereby regulates cell growth.
Mesh Terms:
Animals, Fusion Proteins, bcr-abl, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Mice, Phosphorylation, Protein Binding, Retinoblastoma Protein, Signal Transduction, Tumor Cells, Cultured
Animals, Fusion Proteins, bcr-abl, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Mice, Phosphorylation, Protein Binding, Retinoblastoma Protein, Signal Transduction, Tumor Cells, Cultured
Int. J. Hematol.
Date: Feb. 01, 1997
PubMed ID: 9071815
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