Complexins: cytosolic proteins that regulate SNAP receptor function.
A family of proteins called complexins was discovered that compete with alpha-SNAP, but not synaptotagmin, for SNAP receptor binding. Complexins I and II are highly homologous hydrophilic proteins that are tightly conserved, with 100% identity among mouse, rat, and human complexin II. They are enriched in neurons where they colocalize ... with syntaxin and SNAP-25; in addition, complexin II is expressed ubiquitously at low levels. Complexins bind weakly to syntaxin alone and not at all to synaptobrevin and SNAP-25, but strongly to the SNAP receptor-core complex composed of these three molecules. They compete with alpha-SNAP for binding to the core complex but not with other interacting molecules, including synaptotagmin I, suggesting that the complexins regulate the sequential interactions of alpha-SNAP and synaptotagmins with the SNAP receptor during exocytosis.
Mesh Terms:
Adaptor Proteins, Vesicular Transport, Amino Acid Sequence, Animals, Brain Chemistry, Calcium, Calcium-Binding Proteins, Carrier Proteins, Cytosol, Exocytosis, Gene Expression, Hippocampus, Humans, Macromolecular Substances, Membrane Fusion, Membrane Glycoproteins, Membrane Proteins, Mice, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, R-SNARE Proteins, Rats, Recombinant Fusion Proteins, SNARE Proteins, Sequence Alignment, Sequence Homology, Amino Acid, Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins, Species Specificity, Synaptic Vesicles, Synaptosomal-Associated Protein 25, Synaptotagmin I, Synaptotagmins, Vesicular Transport Proteins
Adaptor Proteins, Vesicular Transport, Amino Acid Sequence, Animals, Brain Chemistry, Calcium, Calcium-Binding Proteins, Carrier Proteins, Cytosol, Exocytosis, Gene Expression, Hippocampus, Humans, Macromolecular Substances, Membrane Fusion, Membrane Glycoproteins, Membrane Proteins, Mice, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, R-SNARE Proteins, Rats, Recombinant Fusion Proteins, SNARE Proteins, Sequence Alignment, Sequence Homology, Amino Acid, Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins, Species Specificity, Synaptic Vesicles, Synaptosomal-Associated Protein 25, Synaptotagmin I, Synaptotagmins, Vesicular Transport Proteins
Cell
Date: Oct. 06, 1995
PubMed ID: 7553862
View in: Pubmed Google Scholar
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