Strong FANCA/FANCG but weak FANCA/FANCC interaction in the yeast 2-hybrid system.
Three of at least 8 Fanconi anemia (FA) genes have been cloned (FANCA, FANCC, FANCG), but their functions remain unknown. Using the yeast 2-hybrid system and full-length cDNA, the authors found a strong interaction between FANCA and FANCG proteins. They also obtained evidence for a weak interaction between FANCA and ... FANCC. Neither FANCA nor FANCC was found to interact with itself. These results support the notion of a functional association between the FA gene products. (Blood. 2000;95:719-720)
Mesh Terms:
Cell Cycle Proteins, Cloning, Molecular, DNA, Complementary, DNA-Binding Proteins, Fanconi Anemia, Fanconi Anemia Complementation Group A Protein, Fanconi Anemia Complementation Group C Protein, Fanconi Anemia Complementation Group G Protein, Fanconi Anemia Complementation Group Proteins, Humans, Nuclear Proteins, Proteins, Recombinant Proteins, Saccharomyces cerevisiae
Cell Cycle Proteins, Cloning, Molecular, DNA, Complementary, DNA-Binding Proteins, Fanconi Anemia, Fanconi Anemia Complementation Group A Protein, Fanconi Anemia Complementation Group C Protein, Fanconi Anemia Complementation Group G Protein, Fanconi Anemia Complementation Group Proteins, Humans, Nuclear Proteins, Proteins, Recombinant Proteins, Saccharomyces cerevisiae
Blood
Date: Jan. 15, 2000
PubMed ID: 10627486
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