Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP.

We report the identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein (hVAP-33) that has been implicated in neuronal exocytosis in Aplysia californica. This hVAP-33 shared 50% amino acid identity with the A. californica form and had similar length, structural organization and VAMP-binding abilities. However, in contrast ...
with the neuron-specific expression seen in A. californica, hVAP-33 was broadly expressed, suggesting possible roles in vesicle fusion in both neuronal and non-neuronal cells.
Mesh Terms:
Amino Acid Sequence, Animals, Base Sequence, Carrier Proteins, Humans, Membrane Proteins, Mice, Molecular Sequence Data, Nerve Tissue Proteins, Protein Binding, Protein Conformation, R-SNARE Proteins, RNA, SNARE Proteins, Synaptic Transmission, Vesicular Transport Proteins
Biochem. J.
Date: Jul. 15, 1998
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