Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP.
We report the identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein (hVAP-33) that has been implicated in neuronal exocytosis in Aplysia californica. This hVAP-33 shared 50% amino acid identity with the A. californica form and had similar length, structural organization and VAMP-binding abilities. However, in contrast ... with the neuron-specific expression seen in A. californica, hVAP-33 was broadly expressed, suggesting possible roles in vesicle fusion in both neuronal and non-neuronal cells.
Mesh Terms:
Amino Acid Sequence, Animals, Base Sequence, Carrier Proteins, Humans, Membrane Proteins, Mice, Molecular Sequence Data, Nerve Tissue Proteins, Protein Binding, Protein Conformation, R-SNARE Proteins, RNA, SNARE Proteins, Synaptic Transmission, Vesicular Transport Proteins
Amino Acid Sequence, Animals, Base Sequence, Carrier Proteins, Humans, Membrane Proteins, Mice, Molecular Sequence Data, Nerve Tissue Proteins, Protein Binding, Protein Conformation, R-SNARE Proteins, RNA, SNARE Proteins, Synaptic Transmission, Vesicular Transport Proteins
Biochem. J.
Date: Jul. 15, 1998
PubMed ID: 9657962
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