BAK1, an Arabidopsis LRR receptor-like protein kinase, interacts with BRI1 and modulates brassinosteroid signaling.
Brassinosteroids regulate plant growth and development through a protein complex that includes the leucine-rich repeat receptor-like protein kinase (LRR-RLK) brassinosteroid-insensitive 1 (BRI1). Activation tagging was used to identify a dominant genetic suppressor of bri1, bak1-1D (bri1-associated receptor kinase 1-1Dominant), which encodes an LRR-RLK, distinct from BRI1. Overexpression of BAK1 results ... in elongated organ phenotypes, while a null allele of BAK1 displays a semidwarfed phenotype and has reduced sensitivity to brassinosteroids (BRs). BAK1 is a serine/threonine protein kinase, and BRI1 and BAK1 interact in vitro and in vivo. Expression of a dominant-negative mutant allele of BAK1 causes a severe dwarf phenotype, resembling the phenotype of null bri1 alleles. These results indicate BAK1 is a component of BR signaling.
Mesh Terms:
Alleles, Arabidopsis, Arabidopsis Proteins, Cholestanols, Enzyme Activation, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Plant, Hydroxysteroids, Membrane Proteins, Phenotype, Phosphorylation, Protein Kinases, Protein-Serine-Threonine Kinases, Repressor Proteins, Signal Transduction, Steroids, Heterocyclic, Tissue Distribution
Alleles, Arabidopsis, Arabidopsis Proteins, Cholestanols, Enzyme Activation, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Plant, Hydroxysteroids, Membrane Proteins, Phenotype, Phosphorylation, Protein Kinases, Protein-Serine-Threonine Kinases, Repressor Proteins, Signal Transduction, Steroids, Heterocyclic, Tissue Distribution
Cell
Date: Jul. 26, 2002
PubMed ID: 12150929
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