The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins.
The c-Myc and E2F transcription factors are among the most potent regulators of cell cycle progression in higher eukaryotes. This report describes the isolation of a novel, highly conserved 434 kDa protein, designated TRRAP, which interacts specifically with the c-Myc N terminus and has homology to the ATM/PI3-kinase family. TRRAP ... also interacts specifically with the E2F-1 transactivation domain. Expression of transdominant mutants of the TRRAP protein or antisense RNA blocks c-Myc- and E1A-mediated oncogenic transformation. These data suggest that TRRAP is an essential cofactor for both the c-Myc and E1A/E2F oncogenic transcription factor pathways.
Mesh Terms:
1-Phosphatidylinositol 3-Kinase, Adaptor Proteins, Signal Transducing, Adenovirus E1A Proteins, Amino Acid Sequence, Carrier Proteins, Cell Cycle Proteins, Cell Transformation, Neoplastic, Conserved Sequence, DNA, Complementary, DNA-Binding Proteins, E2F Transcription Factors, E2F1 Transcription Factor, Evolution, Molecular, Genes, Dominant, Hela Cells, Humans, Molecular Sequence Data, Mutagenesis, Site-Directed, Nuclear Proteins, Oligonucleotides, Antisense, Protein Binding, Protein-Serine-Threonine Kinases, Proteins, Proto-Oncogene Proteins c-myc, Retinoblastoma-Binding Protein 1, Transcription Factor DP1, Transcription Factors, Tumor Suppressor Proteins
1-Phosphatidylinositol 3-Kinase, Adaptor Proteins, Signal Transducing, Adenovirus E1A Proteins, Amino Acid Sequence, Carrier Proteins, Cell Cycle Proteins, Cell Transformation, Neoplastic, Conserved Sequence, DNA, Complementary, DNA-Binding Proteins, E2F Transcription Factors, E2F1 Transcription Factor, Evolution, Molecular, Genes, Dominant, Hela Cells, Humans, Molecular Sequence Data, Mutagenesis, Site-Directed, Nuclear Proteins, Oligonucleotides, Antisense, Protein Binding, Protein-Serine-Threonine Kinases, Proteins, Proto-Oncogene Proteins c-myc, Retinoblastoma-Binding Protein 1, Transcription Factor DP1, Transcription Factors, Tumor Suppressor Proteins
Cell
Date: Aug. 07, 1998
PubMed ID: 9708738
View in: Pubmed Google Scholar
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