Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase.

mTOR immunoprecipitates contain two 4E-BP1 protein kinase activities. One appears to be due to mTOR itself and results in the phosphorylation of 4E-BP1 on residues T(36) and T(45), as shown previously by others. The other is a kinase which can be separated from mTOR and which phosphorylates 4E-BP1 within a ...
peptide(s) containing residues S(64) and T(69). This phosphorylation, which occurs predominantly on S(64), results in the dissociation of 4E-BP1 from eIF-4E.
Mesh Terms:
Amino Acid Sequence, Animals, Carrier Proteins, Eukaryotic Initiation Factor-4E, Male, Molecular Sequence Data, Peptide Initiation Factors, Phosphoproteins, Phosphorylation, Phosphotransferases (Alcohol Group Acceptor), Precipitin Tests, Protein Kinases, Rats, Rats, Wistar, Recombinant Proteins
FEBS Lett.
Date: Sep. 03, 1999
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