c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis.
c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1 structurally and functionally from the positive transcription elongation factor b (P-TEFb). The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phosporylates the C-terminal domain of RNA polymerase II, which is required for the transition from initiation ... to elongation of eukaryotic transcription. Inhibiting P-TEFb blocks the transcription of its target genes as well as cellular proliferation and apoptosis induced by c-Myc.
Mesh Terms:
Animals, Apoptosis, COS Cells, Cell Division, Genes, myc, Positive Transcriptional Elongation Factor B, Protein-Serine-Threonine Kinases, Transcription, Genetic
Animals, Apoptosis, COS Cells, Cell Division, Genes, myc, Positive Transcriptional Elongation Factor B, Protein-Serine-Threonine Kinases, Transcription, Genetic
Oncogene
Date: Aug. 28, 2003
PubMed ID: 12944920
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