Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases.
The neuregulins (NRGs) are a family of multipotent epidermal-growth-factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are ... encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases. However, NRG-2 stimulates different ErbB-receptor tyrosine-phosphorylation profiles from NRG-1. Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells.
Mesh Terms:
Amino Acid Sequence, Animals, Brain, Cell Adhesion, Dimerization, Epidermal Growth Factor, Glycoproteins, Humans, Ligands, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Myocardium, Nerve Growth Factors, Neuregulins, Phosphorylation, Proto-Oncogene Proteins, Receptor, Epidermal Growth Factor, Receptor, erbB-3, Recombinant Proteins, Sequence Homology, Amino Acid, Tumor Cells, Cultured, Tyrosine
Amino Acid Sequence, Animals, Brain, Cell Adhesion, Dimerization, Epidermal Growth Factor, Glycoproteins, Humans, Ligands, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Myocardium, Nerve Growth Factors, Neuregulins, Phosphorylation, Proto-Oncogene Proteins, Receptor, Epidermal Growth Factor, Receptor, erbB-3, Recombinant Proteins, Sequence Homology, Amino Acid, Tumor Cells, Cultured, Tyrosine
Nature
Date: May. 29, 1997
PubMed ID: 9168115
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