Cdc7-Dbf4 regulates NDT80 transcription as well as reductional segregation during budding yeast meiosis.

In budding yeast, as in other eukaryotes, the Cdc7 protein kinase is important for initiation of DNA synthesis in vegetative cells. In addition, Cdc7 has crucial meiotic functions: it facilitates premeiotic DNA replication, and it is essential for the initiation of recombination. This work uses a chemical genetic approach to ...
demonstrate that Cdc7 kinase has additional roles in meiosis. First, Cdc7 allows expression of NDT80, a meiosis-specific transcriptional activator required for the induction of genes involved in exit from pachytene, meiotic progression, and spore formation. Second, Cdc7 is necessary for recruitment of monopolin to sister kinetochores, and it is necessary for the reductional segregation occurring at meiosis I. The use of the same kinase to regulate several distinct meiosis-specific processes may be important for the coordination of these processes during meiosis.
Mesh Terms:
Cell Cycle Proteins, Chromosome Segregation, Chromosomes, Fungal, DNA Breaks, Double-Stranded, DNA-Binding Proteins, Genes, Fungal, Kinetochores, Meiosis, Models, Biological, Mutation, Oligonucleotide Array Sequence Analysis, Protein Transport, Protein-Serine-Threonine Kinases, Pyrazoles, Pyrimidines, Recombination, Genetic, S Phase, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Spores, Fungal, Transcription Factors, Transcription, Genetic
Mol. Biol. Cell
Date: Nov. 01, 2008
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