A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.
We identify a complex of three proteins in brain that has the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. The three proteins are: (1) CASK, a protein related to MAGUKs (membrane-associated guanylate kinases); (2) Mint1, a putative vesicular trafficking protein; and (3) Veli1, -2, and -3, vertebrate ... homologs of C. elegans LIN-7. CASK, Mint1, and Velis form a tight, salt-resistant complex that can be readily isolated. CASK, Mint1, and Velis contain PDZ domains in addition to other modules. However, no PDZ domains are involved in complex formation, leaving them free to recruit cell adhesion molecules, receptors, and channels to the complex. We propose that the tripartite complex acts as a nucleation site for the assembly of proteins involved in synaptic vesicle exocytosis and synaptic junctions.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Animals, Brain Chemistry, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Calcium-Binding Proteins, Calcium-Calmodulin-Dependent Protein Kinases, Carrier Proteins, Cell Adhesion, Cell Membrane, Cloning, Molecular, Exocytosis, Glycoproteins, Guanylate Kinase, Helminth Proteins, Humans, Membrane Glycoproteins, Membrane Proteins, Mice, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Neuropeptides, Nucleoside-Phosphate Kinase, Protein Binding, Rats, Sequence Homology, Amino Acid, Synaptic Vesicles, Synaptophysin, Synaptotagmins, Tumor Suppressor Proteins
Adaptor Proteins, Signal Transducing, Animals, Brain Chemistry, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Calcium-Binding Proteins, Calcium-Calmodulin-Dependent Protein Kinases, Carrier Proteins, Cell Adhesion, Cell Membrane, Cloning, Molecular, Exocytosis, Glycoproteins, Guanylate Kinase, Helminth Proteins, Humans, Membrane Glycoproteins, Membrane Proteins, Mice, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Neuropeptides, Nucleoside-Phosphate Kinase, Protein Binding, Rats, Sequence Homology, Amino Acid, Synaptic Vesicles, Synaptophysin, Synaptotagmins, Tumor Suppressor Proteins
Cell
Date: Sep. 18, 1998
PubMed ID: 9753324
View in: Pubmed Google Scholar
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