Binding of neuroligins to PSD-95.
PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2 receptor) and K+ channels to synapses. In mouse forebrain, PSD-95 bound to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules that interact with beta-neurexins and ... form intercellular junctions. Neuroligins bind to the third PDZ domain of PSD-95, whereas NMDA2 receptors and K+ channels interact with the first and second PDZ domains. Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins.
Mesh Terms:
Amino Acid Sequence, Animals, COS Cells, Calcium-Calmodulin-Dependent Protein Kinases, Cell Line, Cell Membrane, Cytoplasm, Guanylate Kinase, Intercellular Junctions, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Mice, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Nucleoside-Phosphate Kinase, Potassium Channels, Prosencephalon, Receptors, N-Methyl-D-Aspartate, Recombinant Fusion Proteins, Tumor Suppressor Proteins
Amino Acid Sequence, Animals, COS Cells, Calcium-Calmodulin-Dependent Protein Kinases, Cell Line, Cell Membrane, Cytoplasm, Guanylate Kinase, Intercellular Junctions, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Mice, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Nucleoside-Phosphate Kinase, Potassium Channels, Prosencephalon, Receptors, N-Methyl-D-Aspartate, Recombinant Fusion Proteins, Tumor Suppressor Proteins
Science
Date: Sep. 05, 1997
PubMed ID: 9278515
View in: Pubmed Google Scholar
Download Curated Data For This Publication
8595
Switch View:
- Interactions 17