IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription.
Jun-dimerization protein 2 (JDP2) is a member of the activating protein-1 (AP-1) family of transcription factors. JDP2 dimerizes with other AP-1 proteins such as activating transcription factor-2 (ATF2) and Jun to repress transcription from promoters that contain a cyclic AMP-responsive element (CRE). Interferon regulatory factor-2-binding protein-1 (IRF2-BP1), which is reported ... to be a transcriptional corepressor of IRF2, was isolated as a JDP2-binding protein using an epitope-tagging method. As anticipated from the presence of a RING-finger domain, IRF2-BP1 enhanced the polyubiquitination of JDP2. Moreover, IRF2-BP1 repressed ATF2-mediated transcriptional activation from a CRE-containing promoter.
Mesh Terms:
Activating Transcription Factor 2, Amino Acid Sequence, Carrier Proteins, Genes, Reporter, Hela Cells, Humans, Luciferases, Molecular Sequence Data, Promoter Regions, Genetic, Repressor Proteins, Transcription, Genetic, Transcriptional Activation, Ubiquitin-Protein Ligases, Ubiquitination
Activating Transcription Factor 2, Amino Acid Sequence, Carrier Proteins, Genes, Reporter, Hela Cells, Humans, Luciferases, Molecular Sequence Data, Promoter Regions, Genetic, Repressor Proteins, Transcription, Genetic, Transcriptional Activation, Ubiquitin-Protein Ligases, Ubiquitination
FEBS Lett.
Date: Aug. 20, 2008
PubMed ID: 18671972
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