The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations.

Bright is an ARID family transcription factor that increases immunoglobulin heavy chain transcription. In the mouse, Bright expression is tightly regulated and B cell-restricted and the Bright protein associates with Bruton's tyrosine kinase (Btk), the defective enzyme in X-linked immunodeficiency. Human X-linked agammaglobulinemia results from defects in Btk and leads ...
to early blocks in B lymphocyte development. Because so little is known about human Bright, we sought to determine where human Bright is expressed in normal B cell differentiation and whether it also forms complexes with Btk. Although human and mouse Bright exhibited similar expression patterns in normal B cells, many human transformed B cell lines did not express Bright protein. However, the human protein bound prototypic Bright DNA-binding motifs and, like mouse Bright, was capable of associating with Btk. These data suggest potentially important similarities exist in Bright expression and activity in human and mouse B lymphocytes.
Mesh Terms:
B-Lymphocyte Subsets, Base Sequence, Binding Sites, Cell Line, Transformed, Consensus Sequence, DNA, DNA-Binding Proteins, Gene Expression, Germinal Center, Humans, Oncogenes, Protein-Tyrosine Kinases, Stem Cells, Tissue Distribution, Trans-Activators, Transcription Factors
Cell. Immunol.
Date: Mar. 01, 2004
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