A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins.

We have characterized a novel partner for androgen receptor (AR), termed ARIP3, that interacts with the DNA-binding domain/zinc finger region of AR and is predominantly expressed in the testis. Rat ARIP3 is a nuclear protein comprising 572 amino acids. It modulates AR-dependent but not basal transcription, suggesting that ARIP3 acts ...
as an AR transcriptional coregulator. Except for the C-terminal AR-interacting domain, ARIP3 contains distinct regions that are also present in two recently described proteins, a protein inhibitor of activated Stat3 and an RNA helicase II-interacting protein (Gu/RH-II binding protein). Conserved structural features of these proteins indicate the existence of a gene family involved in the regulation of various transcription factors. Collectively, ARIP3 belongs to a novel nuclear protein family and is perhaps the first tissue-specific coregulator of androgen receptor.
Mesh Terms:
Amino Acid Sequence, Animals, COS Cells, Male, Molecular Sequence Data, Nuclear Proteins, Protein Binding, Rats, Receptors, Androgen, Sequence Homology, Amino Acid, Subcellular Fractions, Testis, Transcription, Genetic, Transfection, Zinc Fingers
J. Biol. Chem.
Date: Feb. 05, 1999
Download Curated Data For This Publication
8873
Switch View:
  • Interactions 2