Activation of interferon regulatory factor 3 in response to DNA-damaging agents.
Genotoxic stress triggers signal transduction pathways that mediate either the protection or apoptosis of affected cells. The interferon regulatory factors (IRFs) are involved in a wide range of host defense mechanisms against environmental stresses. Treatment with DNA-damaging agents, including doxorubicin and UV radiation, caused phosphorylation of the IRF3 transcription factor. ... Phosphorylation of IRF3 induced its interaction with the transcriptional co-activator cAMP-response element binding protein-binding protein. Furthermore, genotoxic stress-induced phosphorylation of IRF3 resulted in its movement from the cytoplasm to the nucleus, where it activated transcription from its binding site. These observations suggest that IRF3 plays a role in the defensive responses induced by genotoxic stress.
Mesh Terms:
Amino Acid Substitution, Cell Nucleus, DNA Damage, DNA-Binding Proteins, Doxorubicin, Hela Cells, Humans, Interferon Regulatory Factor-3, Mutagenesis, Site-Directed, Phosphorylation, Recombinant Proteins, Signal Transduction, Transcription Factors, Transfection, Ultraviolet Rays
Amino Acid Substitution, Cell Nucleus, DNA Damage, DNA-Binding Proteins, Doxorubicin, Hela Cells, Humans, Interferon Regulatory Factor-3, Mutagenesis, Site-Directed, Phosphorylation, Recombinant Proteins, Signal Transduction, Transcription Factors, Transfection, Ultraviolet Rays
J. Biol. Chem.
Date: Oct. 22, 1999
PubMed ID: 10521456
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