Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway.
Many cytokines transmit signals to the cell interior through activation of receptor-associated, Janus family protein tyrosine kinases (Jak PTKs). The interleukin-2 receptor (IL-2R) is associated with the Jak1 and Jak3 PTKs, and ligand-induced activation of these PTKs is essential for lymphocyte proliferation. Here, the nonreceptor PTK, Pyk2, was found to ... be activated following IL-2 stimulation in a Jak-dependent manner. Furthermore, physical association was detected between endogenous Pyk2 and Jak3, and a dominant interfering mutant of Pyk2 inhibited IL-2-induced cell proliferation without affecting Stat5 activation. Collectively, these results suggest that Pyk2 is a newly identified component of the Jak-mediated IL-2 signaling pathway.
Mesh Terms:
Binding Sites, Cell Division, Cells, Cultured, DNA-Binding Proteins, Enzyme Activation, Focal Adhesion Kinase 2, Humans, Interleukin-2, Janus Kinase 3, Milk Proteins, Protein-Tyrosine Kinases, Receptors, Interleukin-2, STAT5 Transcription Factor, Signal Transduction, Trans-Activators
Binding Sites, Cell Division, Cells, Cultured, DNA-Binding Proteins, Enzyme Activation, Focal Adhesion Kinase 2, Humans, Interleukin-2, Janus Kinase 3, Milk Proteins, Protein-Tyrosine Kinases, Receptors, Interleukin-2, STAT5 Transcription Factor, Signal Transduction, Trans-Activators
Genes Dev.
Date: Mar. 15, 1998
PubMed ID: 9512511
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