Polycomb group protein ezh2 controls actin polymerization and cell signaling.
Polycomb group protein Ezh2, one of the key regulators of development in organisms from flies to mice, exerts its epigenetic function through regulation of histone methylation. Here, we report the existence of the cytosolic Ezh2-containing methyltransferase complex and tie the function of this complex to regulation of actin polymerization in ... various cell types. Genetic evidence supports the essential role of cytosolic Ezh2 in actin polymerization-dependent processes such as antigen receptor signaling in T cells and PDGF-induced dorsal circular ruffle formation in fibroblasts. Revealed function of Ezh2 points to a broader usage of lysine methylation in regulation of both nuclear and extra-nuclear signaling processes.
Mesh Terms:
Actins, Animals, Antigen Presentation, Carrier Proteins, Cell Cycle Proteins, Cell Differentiation, Cell Proliferation, Cytoplasm, DNA-Binding Proteins, Fibroblasts, Histone-Lysine N-Methyltransferase, Humans, Jurkat Cells, Lymphocyte Activation, Mice, Mice, Inbred C57BL, Mice, Transgenic, Nuclear Proteins, Platelet-Derived Growth Factor, Protein Methyltransferases, Proteins, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-vav, Receptors, Antigen, T-Cell, Repressor Proteins, Signal Transduction, T-Lymphocytes, Thymus Gland, Transcription Factors, cdc42 GTP-Binding Protein
Actins, Animals, Antigen Presentation, Carrier Proteins, Cell Cycle Proteins, Cell Differentiation, Cell Proliferation, Cytoplasm, DNA-Binding Proteins, Fibroblasts, Histone-Lysine N-Methyltransferase, Humans, Jurkat Cells, Lymphocyte Activation, Mice, Mice, Inbred C57BL, Mice, Transgenic, Nuclear Proteins, Platelet-Derived Growth Factor, Protein Methyltransferases, Proteins, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-vav, Receptors, Antigen, T-Cell, Repressor Proteins, Signal Transduction, T-Lymphocytes, Thymus Gland, Transcription Factors, cdc42 GTP-Binding Protein
Cell
Date: May. 06, 2005
PubMed ID: 15882624
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