New insights into BS69 functions.

INSERM U59O and U412, Centre Leon Berard, Universite Claude Bernard Lyon I, 28 rue Laennec, F-69008 Lyon, France.
The BS69 protein has been commonly described as a co-repressor associated with various transcription factors. However, this hypothesis relied predominantly on overexpression of tagged proteins due to the lack of a reliable BS69 antibody. We present for the first time a complete sequence of BS69 and valuable tools to characterize the endogenous protein. We show that the full-length BS69 protein, as well as minor alternatively spliced isoforms, is ubiquitously expressed, nuclear, and associates with chromatin and mitotic chromosomes. Accordingly, BS69 interacts with a set of chromatin remodeling factors, including ATP-dependent helicases, histone deacetylases, and histone methyltransferases, as well as the E2F6 transcription factor. These data strengthen a role for BS69 in gene repression and link BS69 to chromatin remodeling.
Mesh Terms:
Alternative Splicing, Amino Acid Sequence, Animals, Carrier Proteins, Cell Line, Cell Nucleus, Chromatin, Histone-Lysine N-Methyltransferase, Humans, Mice, Molecular Sequence Data, Protein Isoforms, Protein Methyltransferases, Ubiquitin
J. Biol. Chem. Jun. 16, 2006; 281(24);16546-50 [PUBMED:16565076]
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