SBF transcription factor complex positively regulates UV mutagenesis in Saccharomyces cerevisiae.
The collection of gene deletion mutants of Saccharomyces cerevisiae was used to screen for novel genes required for UV-induced mutagenesis. We found the SBF transcription factor (Swi4/Swi6 protein complex) to be required for wild-type levels of UV mutability in forward and reverse mutation assays. Expression of translesion polymerase zeta component ... Rev7 was identified as a target of SBF-dependent regulation.
Mesh Terms:
DNA-Directed DNA Polymerase, Gene Deletion, Gene Expression Regulation, Fungal, Mutagenesis, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Transcription Factors, Ultraviolet Rays
DNA-Directed DNA Polymerase, Gene Deletion, Gene Expression Regulation, Fungal, Mutagenesis, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Transcription Factors, Ultraviolet Rays
Biochem. Biophys. Res. Commun.
Date: Feb. 20, 2009
PubMed ID: 19150335
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