Solution structure of the BRK domains from CHD7.
CHD7 is a member of the chromodomain helicase DNA binding domain (CHD) family of ATP-dependent chromatin remodelling enzymes. It is mutated in CHARGE syndrome, a multiple congenital anomaly condition. CHD7 is one of a subset of CHD proteins, unique to metazoans that contain the BRK domain, a protein module also ... found in the Brahma/BRG1 family of helicases. We describe here the NMR solution structure of the two BRK domains of CHD7. Each domain has a compact betabetaalphabeta fold. The second domain has a C-terminal extension consisting of two additional helices. The structure differs from those of other domains present in chromatin-associated proteins.
Mesh Terms:
Amino Acid Sequence, Animals, DNA Helicases, DNA-Binding Proteins, Drosophila melanogaster, Glutathione Transferase, Humans, Ligands, Magnetic Resonance Spectroscopy, Molecular Conformation, Molecular Sequence Data, Protein Binding, Protein Conformation, Protein Folding, Protein Structure, Secondary, Protein Structure, Tertiary
Amino Acid Sequence, Animals, DNA Helicases, DNA-Binding Proteins, Drosophila melanogaster, Glutathione Transferase, Humans, Ligands, Magnetic Resonance Spectroscopy, Molecular Conformation, Molecular Sequence Data, Protein Binding, Protein Conformation, Protein Folding, Protein Structure, Secondary, Protein Structure, Tertiary
J. Mol. Biol.
Date: Aug. 31, 2007
PubMed ID: 17603073
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