Neurofibromin homologs Ira1 and Ira2 affect glycerophosphoinositol production and transport in Saccharomyces cerevisiae.

Saccharomyces cerevisiae produces extracellular glycerophosphoinositol through phospholipase-mediated turnover of phosphatidylinositol and transports glycerophosphoinositol into the cell upon nutrient limitation. A screening identified the RAS GTPase-activating proteins Ira1 and Ira2 as required for utilization of glycerophosphoinositol as the sole phosphate source, but the RAS/cyclic AMP pathway does not appear to be ...
involved in the growth phenotype. Ira1 and Ira2 affect both the production and transport of glycerophosphoinositol.
Mesh Terms:
Biological Transport, GTPase-Activating Proteins, Inositol Phosphates, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Eukaryotic Cell
Date: Nov. 01, 2009
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