The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.

Apoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the inactive zymogen, as occurs in the caspase-9-activating apoptosome complex. Likewise, caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. We show that activation of caspase-2 ...
occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Because PIDD functions in p53-mediated apoptosis, the complex assembled by PIDD and caspase-2 is likely to regulate apoptosis induced by genotoxins.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Apoptosis, CRADD Signaling Adaptor Protein, Carrier Proteins, Caspase 2, Caspases, Cell Line, Cell Line, Tumor, Cloning, Molecular, DNA Damage, Doxorubicin, Enzyme Activation, Etoposide, Humans, Protein Structure, Tertiary, Proteins, RNA, Small Interfering, Signal Transduction, Transfection, Tumor Suppressor Protein p53
Science
Date: May. 07, 2004
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